Histamine, Neuroinflammation and Neurodevelopment: A Review

The biogenic amine, histamine, has been shown to critically modulate inflammatory processes as well the properties of neurons and synapses in brain, is also implicated emergence neurodevelopmental disorders. Indeed, a reduction synthesis this neuromodulator associated with disorders Tourette’s syndrome obsessive-compulsive disorder, evidence that may be through disruption corticostriatal circuitry during development. Furthermore, neuroinflammation alterations brain development, e.g., impacting synaptic plasticity synaptogenesis, there are suggestions histamine deficiency leave developing more vulnerable proinflammatory insults. While most studies have focused on neuronal sources it remains unclear what extent other (non-neuronal) from mast cells sources, can impact few started exploring vitro , limited vivo would indicate non-neuronal released preformed mediators influence microglial-mediated which In Review we will summarize state field regard its both development key neural circuits underpin We discuss whether receptor modulators efficacious treatment preclinical clinical studies. This could represent an important area future research early modulation provide novel therapeutic targets these